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Last name: COLLIOT
First name: Olivier
International audience
Multiple sclerosis (MS) is the most common demyelinating disease. In MS, demyelination occurs in the white matter of the brain and in the spinal cord. It is thus essential to measure the tissue myelin content to understand the physiopathology of MS, track progression and assess treatment efficacy. Positron emission tomography (PET) with...
This paper summarizes our contribution to the MSSEG-II MICCAI 2021 challenge. The aim is to segment new multiple sclerosis (MS) lesions using pairs of FLAIR MR images. Our approach is based on a 3D U-Net applied patch-wise to the images. In order to take into account both time-points, we simply concatenate the images along the channel axis...
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). A reliable measure of the tissue myelin content is therefore essential to understand the physiopathology of MS, track progression and assess treatment efficacy. Positron emission tomography (PET) with [ 11 C]PIB has been proposed as a promising biomarker for...
Multiple sclerosis (MS) is a white matter (WM) disease characterized by the formation of WM lesions, which can be visualized by magnetic resonance imaging (MRI). The fluid-attenuated inversion recovery (FLAIR) MRI pulse sequence is used clinically and in research for the detection of WM lesions. However, in clinical settings, some MRI pulse...
Synopsis. Fluid-attenuated inversion recovery (FLAIR) MRI pulse sequence is used clinically and in research for the detection of WM lesions. However,in a clinical setting, some MRI pulse sequences can be missing because of patient or time constraints. We propose 3D fully convolutional neural networks to predict a FLAIR MRI pulse sequence from...
Detecting new lesions is a key aspect of the radiological follow-up of patients with Multiple Sclerosis (MS), leading to eventual changes in their therapeutics. Our pipeline for new lesion detection based on two consecutive FLAIR MRIs consists in two steps. We start by a detection of potential Region Of Interest (ROI) containing new lesions...
Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system (CNS). The de-myelination process can be repaired by the generation of a new sheath of myelin around the axon, a process termed remyelination. In MS patients, the demyelination-remyelination cycles are highly dynamic. Over the years, magnetic...
Detecting new lesions is a key aspect of the radiological follow-up of patients with Multiple Sclerosis (MS), leading to eventual changes in their therapeutics. This paper presents our contribution to the MSSEG-2 MICCAI 2021 challenge. The challenge is focused on the segmentation of new MS lesions using two consecutive Fluid Attenuated...
The brain is composed of several neural circuits which may be seen as anatomical complexes composed of grey matter structures interconnected by white matter tracts. Grey and white matter components may be modelled as 3D surfaces and curves respectively. Neurodevelopmental disorders involve morphological and organizational alterations which can...
Multiple sclerosis (MS) is a demyenalinating inflammatory neurological disease. In vivo biomarkers of myelin content are of major importance for patient care and clinical trials. Positron Emission Tomography (PET) with Pittsburgh Compound B (PiB) provides a specific myelin marker. However, it is not available in clinical routine. In this paper,...
OBJECTIVE:Cortical thinning, previously identified during prodromal stages of Alzheimer's disease (AD), is a "candidate" biomarker implemented in AD clinical therapy trials. We investigated the effect of donepezil treatment on cortical thickness in mild cognitively impaired subjects with the amnestic syndrome of the hippocampal type, a...